EYECARE: Coronavirus BRIEFING: Crisis Response Tactics LA Has Imposed One of the U.S.’s Strictest Vaccine Mandates. Will It Prevent a COVID Surge? By Staff Friday, November 19, 2021 12:04 AM "The upside of mandates, they definitely work. The downside of the mandates is they can definitely polarize individuals."Annette Regan, an expert in vaccine epidemiology at the University of California, Los Angeles (UCLA), commenting in the recent report by The Guardian, “LA Has Imposed One of the U.S.’s Strictest Vaccine Mandates. Will It Prevent a COVID Surge?”