EYECARE: Coronavirus BRIEFING: Crisis Response Tactics COVID Viral Loads Decreased With Metformin, Study Shows By Staff Friday, May 3, 2024 6:09 AM SARS-CoV-2 viral loads were sharply decreased with metformin, according to a placebo-controlled trial. In this randomized, placebo-controlled trial of outpatient treatment of SARS-CoV-2, Metformin significantly reduced SARS-CoV-2 viral load, which may explain the clinical benefits in this trial. Metformin is pleiotropic with other actions that are relevant to COVID-19 pathophysiology. Click here to read the full story.