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Newborns whose mothers received at least one mRNA COVID-19 vaccine during pregnancy had no worse outcomes than those whose mothers didn't get the vaccine during pregnancy, a large cohort study from Sweden and Norway found.

In fact, the unadjusted mortality rates for vaccine-exposed neonates in the two nations were about half of those for unexposed neonates, a difference that held up after adjustment for a variety of factors (adjusted odds ratio [aOR] 0.68, 95% CI 0.50-0.91), Mikael Norman, MD, PhD, from the Karolinska Institutet in Stockholm, and colleagues reported in JAMA.

Researchers adjusted for factors that included maternal age, BMI, education, country of birth, smoking status, season of conception, parity, multiple births, and gestational age. The findings were unaltered even after restricting the analyses to women without COVID-19 in pregnancy, infants born at term, infants without birth defects, and singleton births, Norman explained.

"We did not expect the lower risk for neonatal death to be so robust," Norman told MedPage Today. Head over to MedPage Today to read more about it.